Clinical Evidence
Clinical trials behind Clickless
Our clinical program is designed to generate the evidence clinicians expect before adopting a new treatment. Figures below are drawn from our published multicenter trial (JMIR 2025;27:e83545).
Study overview
Study type
Double-blind, randomized, sham-controlled trial
Participants
102 randomized, 93 completed per-protocol
Duration
6-week intervention
Sites
2 university hospitals, South Korea
Primary Outcomes
Measured against a sham-controlled comparator
Both arms received conventional TMD care; the trial isolated the added effect of Clickless against a matched sham app.
Pain score, baseline to week 6
VAS 0–100 scale, JMIR 2025;27:e83545
50.6
Clickless, baseline
16.9
Clickless, W6
47.6
Sham, baseline
37.7
Sham, W6
Per-protocol completion rate
% of randomized patients, JMIR 2025;27:e83545
88%
Clickless (n=50)
94%
Sham (n=52)
Mean pain reduction
Clickless arm, baseline to week 6
Program completion
44 of 50 Clickless participants completed
Jaw function improvement
JFLS-20 reduction, Clickless arm, baseline to week 6
Between-group difference in pain reduction: −23.78 (95% CI −34.15 to −13.41; P<.001) vs. sham. Between-group difference in JFLS-20: −1.02 (95% CI −1.63 to −0.42; P=.005).
Publications
Journal publications
Future Studies
What we're studying next
01
Long-term follow-up study
12-month outcome tracking to assess durability of pain reduction.
02
Real-world evidence registry
Post-market data collection across prescribing clinics.
03
Pediatric and adolescent feasibility study
Evaluating program design for younger patient populations.
Primary outcome figures above are from our published multicenter trial (JMIR 2025;27:e83545). Future studies below are in planning.